Search results of triples

A total of 119 records found

#22219 high Confidence
Subject: nucleolus (Subcellular structure)
is_hub_of
Object: ribosome_biogenesis (Molecular complex function)
Original: Nucleolus#is#hub of ribosome biogenesis
🏥 not_specified 📄 PMID: 35255831
#22199 high Confidence
Subject: nucleolus (Organelles)
is
Object: subnuclear_compartment (Subcellular structure)
Original: nucleolus#is#a subnuclear compartment with key roles in rRNA synthesis and ribosome biogenesis
🏥 not_specified 📄 PMID: 30988155
#22117 high Confidence
Subject: RPS14 (Ribosomal proteins)
inhibits
Object: CDK6 (Kinase)
Original: RPS14#acts as#a CDK4/6 inhibitor linking ribosome biogenesis defects to cell cycle progression
🏥 Cell cycle regulation 🧬 RPS14/CDK4/CDK6 📄 PMID: 30706966
#22116 high Confidence
Subject: RPS14 (Ribosomal proteins)
inhibits
Object: CDK4 (Kinase)
Original: RPS14#acts as#a CDK4/6 inhibitor linking ribosome biogenesis defects to cell cycle progression
🏥 Cell cycle regulation 🧬 RPS14/CDK4/CDK6 📄 PMID: 30706966
#22111 high Confidence
Subject: hyperactivation_of_ribosome_biogenesis (Molecular Process)
drives
Object: cancer_progression (Tumor progression)
Original: Hyperactivation of ribosome biogenesis#drives#cancer progression
🏥 Tumor progression 📄 PMID: 39788980
#22106 high Confidence
Subject: nucleolus (Subcellular structure)
is_the_site_of
Object: ribosome_biogenesis (Molecular Process)
Original: The nucleolus#is the site of#ribosome biogenesis
🏥 not_specified 📄 PMID: 28085118
#22006 high Confidence
Subject: nucleolus (Organelles)
plays_key_role_in
Object: ribosome_biogenesis (Molecular Process)
Original: nucleolus#is#a subnuclear compartment with key roles in rRNA synthesis and ribosome biogenesis
🏥 not_specified 📄 PMID: 30988155
#22005 high Confidence
Subject: nucleolus (Organelles)
plays_key_role_in
Object: rRNA_synthesis (Molecular Process)
Original: nucleolus#is#a subnuclear compartment with key roles in rRNA synthesis and ribosome biogenesis
🏥 not_specified 📄 PMID: 30988155
#21652 high Confidence
Subject: NPM1 (Nucleolar proteins)
facilitates
Object: ribosome_biogenesis (Molecular complex synthesis)
Original: NPM1#facilitates#ribosome biogenesis and nucleolar stress responses
🏥 not_specified 🧬 NPM1 📄 PMID: 39528457
#21651 high Confidence
Subject: Ribosome_biogenesis (Biological Process)
is_initiated_in
Object: nucleolus (Cellular substructure)
Original: Ribosome biogenesis#is initiated in#nucleolus
🏥 not_specified 📄 PMID: 27265389
#21650 high Confidence
Subject: nucleolus (Subcellular structure)
is_involved_in
Object: ribosome_subunit_biogenesis (Molecular Process)
Original: Nucleolus#is involved in#ribosome subunit biogenesis/ cell cycle control/ and stress responses
🏥 not_specified 📄 PMID: 16819967
#21593 high Confidence
Subject: nucleolus (Organelles)
fulfills
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: nucleolus#fulfills#crucial functions in ribosome biogenesis
🏥 not_specified 📄 PMID: 32640701
#21585 high Confidence
Subject: c-Myc (Transcription Factors)
regulates
Object: cell_proliferation (Cell proliferation)
Original: c-Myc#regulates#ribosomal RNA synthesis/ ribosome biogenesis/ and cell proliferation
🏥 not_specified 🧬 MYC 📄 PMID: 24481446
#21584 high Confidence
Subject: c-Myc (Transcription Factors)
regulates
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: c-Myc#regulates#ribosomal RNA synthesis/ ribosome biogenesis/ and cell proliferation
🏥 not_specified 🧬 MYC 📄 PMID: 24481446
#21583 high Confidence
Subject: c-Myc (Transcription Factors)
regulates
Object: ribosomal_RNA_synthesis (Ribosomal RNA synthesis)
Original: c-Myc#regulates#ribosomal RNA synthesis/ ribosome biogenesis/ and cell proliferation
🏥 not_specified 🧬 MYC 📄 PMID: 24481446
#21576 high Confidence
Subject: nucleolus (Subcellular structure)
is_involved_in
Object: ribosome_biogenesis (Molecular Process)
Original: The nucleolus#is involved in#ribosomal RNA synthesis/ ribosome biogenesis/ and stress response
🏥 not_specified 📄 PMID: 35325178
#21575 high Confidence
Subject: nucleolus (Subcellular structure)
is_involved_in
Object: ribosomal_RNA_synthesis (Molecular Process)
Original: The nucleolus#is involved in#ribosomal RNA synthesis/ ribosome biogenesis/ and stress response
🏥 not_specified 📄 PMID: 35325178
#21574 high Confidence
Subject: nucleolus (Subcellular structure)
is
Object: nuclear_subcompartment_for_ribosome_subunit_biogenesis (Subcellular structure function)
Original: Nucleolus#is#a nuclear subcompartment for rRNA production and ribosome subunit biogenesis
🏥 not_specified 📄 PMID: 27416361
#21573 high Confidence
Subject: nucleolus (Subcellular structure)
is
Object: nuclear_subcompartment_for_rRNA_production (Subcellular structure function)
Original: Nucleolus#is#a nuclear subcompartment for rRNA production and ribosome subunit biogenesis
🏥 not_specified 📄 PMID: 27416361
#21569 high Confidence
Subject: NCL (Ribosome-associated proteins)
is_involved_in
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: NCL#is involved in#ribosome biogenesis
🏥 not_specified 🧬 NCL 📄 PMID: 28751161
#21564 high Confidence
Subject: ribosome_biogenesis (Ribosome biogenesis)
disruption_kills
Object: tumor_cells (cancer cell)
Original: Disruption of ribosome biogenesis#kills#tumor cells via nucleolar function disruption
🏥 treat 🧬 TP53 📄 PMID: 25464032
#21563 high Confidence
Subject: cancer_cells (cancer cell)
exhibit
Object: increased_ribosome_biogenesis (Ribosome biogenesis)
Original: Cancer cells#exhibit#large nucleoli and increased ribosome biogenesis
🏥 Tumor characteristics 📄 PMID: 26206377
#21562 high Confidence
Subject: cancer_cells (cancer cell)
exhibit
Object: large_nucleoli (Cellular substructure)
Original: Cancer cells#exhibit#large nucleoli and increased ribosome biogenesis
🏥 Tumor characteristics 📄 PMID: 26206377
#21427 high Confidence
Subject: Bortezomib (Proteasome inhibitors)
interferes_with
Object: protein_biosynthesis_at_nucleolar_ribosome_biogenesis_stage (Molecular Process)
Original: bortezomib#interferes with#protein biosynthesis at nucleolar ribosome biogenesis stage
🏥 Treatment Mechanism 📄 PMID: 27567537
#20582 high Confidence
Subject: nucleolus (Cellular substructure)
acts_as
Object: site_of_ribosome_biogenesis (Cellular Processes)
Original: Nucleoli#act as#sites of ribosome biogenesis and hubs that trap proteins
🏥 not_specified 📄 PMID: 34884928
#20581 high Confidence
Subject: nucleolus (Cellular substructure)
is_related_to
Object: functions_in_ribosome_biogenesis (Cellular Processes)
Original: The structure of human nucleoli#is related to#its functions in ribosome biogenesis
🏥 not_specified 📄 PMID: 25670395
#20455 high Confidence
Subject: NPM1 (Protein coding genes)
is_critical_in
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: Nucleophosmin (NPM)#is critical in#ribosome biogenesis
🏥 Ribosome production mechanism 🧬 NPM1 📄 PMID: 22665062
#20449 high Confidence
Subject: nucleolus (Cellular substructure)
has_central_role_in
Object: ribosome_biogenesis (Molecular complex synthesis process)
Original: Nucleolus#has a central role in#ribosome biogenesis
🏥 not_specified 📄 PMID: 34101354
#20444 high Confidence
Subject: nucleolus (Subcellular structure)
plays_central_role_in
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: Nucleolus#plays a central role in#ribosome biogenesis
🏥 not_specified 📄 PMID: 39120297
#20441 high Confidence
Subject: mTORC1 (Protein complex)
regulates
Object: ribosome_biogenesis_events_in_nucleoli (Nucleolar ribosome)
Original: mTORC1#regulates#ribosome biogenesis events in nucleoli
🏥 not_specified 🧬 MTOR 📄 PMID: 22121221
#20428 high Confidence
Subject: NPM1 (Nucleolar proteins)
plays_key_role_in
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: NPM1#plays key roles in#ribosome biogenesis/ centrosome duplication/ genomic stability/ cell cycle progression/ and apoptosis
🏥 not_specified 🧬 NPM1 📄 PMID: 19569254
#20422 high Confidence
Subject: Fibrillarin (Ribosomal proteases)
performs
Object: ribomethylation in eukaryotic ribosomes (Molecular modification events)
Original: Fibrillarin#performs#ribomethylation in eukaryotic ribosomes
🏥 Ribosome biogenesis 🧬 FBL 📄 PMID: 34775914
#20403 high Confidence
Subject: aberrant_ribosome_biogenesis (Abnormal ribosome)
contributes_to
Object: cellular_transformation (Cell transformation)
Original: Aberrant ribosome biogenesis and epigenetic control disruption#contribute to#cellular transformation
🏥 not_specified 📄 PMID: 17994099
#20394 high Confidence
Subject: mTORC1 (Protein complex)
promotes
Object: ribosome_biogenesis (Ribosome biogenesis process)
Original: mTORC1#promotes#ribosome biogenesis
🏥 not_specified 🧬 MTOR 📄 PMID: 22121221
#20373 high Confidence
Subject: nucleolus (Subcellular structure)
plays_key_role_in
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: The nucleolus#plays#a key role in ribosome biogenesis
🏥 Cellular protein synthesis 📄 PMID: 12485873
#20093 high Confidence
Subject: tumorigenesis (Tumor development process)
is_linked_to
Object: ribosome_biogenesis (Cellular Processes)
Original: Tumorigenesis#is linked to#ribosome biogenesis
🏥 Tumorigenesis 📄 PMID: 24884608
#20092 high Confidence
Subject: Nucleophosmin_1 (Nucleolar proteins)
regulates
Object: ribosome_biogenesis (Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
🏥 not_specified 🧬 NPM1 📄 PMID: 36008542
#20091 high Confidence
Subject: Nucleophosmin_1 (Nucleolar proteins)
regulates
Object: centrosome_duplication (Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
🏥 not_specified 🧬 NPM1 📄 PMID: 36008542
#20071 high Confidence
Subject: MYC (Protein coding genes)
activates
Object: RNA_polymerase_I_transcription (Transcription process)
Original: c-Myc#activates#RNA polymerase I-mediated transcription of ribosomal RNA genes
🏥 Ribosome biogenesis 🧬 MYC 📄 PMID: 22665062
#20000 high Confidence
Subject: Nucleophosmin_1 (Nucleolar proteins)
regulates
Object: nucleolar_stress_response (Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
🏥 not_specified 🧬 NPM1 📄 PMID: 36008542
#19918 middle Confidence
Subject: NPM1 (Nucleolar proteins)
facilitates
Object: nucleolar_stress_response (Cellular stress response)
Original: NPM1#facilitates#ribosome biogenesis and nucleolar stress responses
🏥 not_specified 🧬 NPM1 📄 PMID: 39528457
#19883 middle Confidence
Subject: NOLC1 (Nucleolus-associated protein)
promotes
Object: rRNA_transcription (Transcription process)
Original: NOLC1#promotes#rRNA transcription in ribosome biogenesis
🏥 not_specified 🧬 NOLC1 📄 PMID: 35365782
#19195 middle Confidence
Subject: NGDN (Ribosome-associated proteins)
forms_complex_with
Object: NOL10 (Ribosome-associated proteins)
Original: AATF protein#forms#a complex with NGDN and NOL10 for ribosome biogenesis
🏥 not_specified 🧬 AATF/NGDN/NOL10 📄 PMID: 27599843
#19194 middle Confidence
Subject: AATF_protein (Ribosome-associated proteins)
forms_complex_with
Object: NOL10 (Ribosome-associated proteins)
Original: AATF protein#forms#a complex with NGDN and NOL10 for ribosome biogenesis
🏥 not_specified 🧬 AATF/NGDN/NOL10 📄 PMID: 27599843
#19193 middle Confidence
Subject: AATF_protein (Ribosome-associated proteins)
forms_complex_with
Object: NGDN (Ribosome-associated proteins)
Original: AATF protein#forms#a complex with NGDN and NOL10 for ribosome biogenesis
🏥 not_specified 🧬 AATF/NGDN/NOL10 📄 PMID: 27599843
#19184 middle Confidence
Subject: nucleolus (Subcellular structure)
is_involved_in
Object: cell_cycle_control (Cellular Processes)
Original: Nucleolus#is involved in#ribosome subunit biogenesis/ cell cycle control/ and stress responses
🏥 not_specified 📄 PMID: 16819967
#19083 middle Confidence
Subject: p53 (Transcription Factors)
regulates
Object: ribosome_biogenesis (Molecular complex assembly)
Original: p53#regulates#ribosome biogenesis
🏥 not_specified 🧬 TP53 📄 PMID: 20332106
#19071 middle Confidence
Subject: NPM1 (Nucleolar proteins)
plays_key_role_in
Object: apoptosis (Apoptosis)
Original: NPM1#plays key roles in#ribosome biogenesis/ centrosome duplication/ genomic stability/ cell cycle progression/ and apoptosis
🏥 not_specified 🧬 NPM1 📄 PMID: 19569254
#19070 middle Confidence
Subject: NPM1 (Nucleolar proteins)
plays_key_role_in
Object: cell_cycle_progression (Cell cycle progression)
Original: NPM1#plays key roles in#ribosome biogenesis/ centrosome duplication/ genomic stability/ cell cycle progression/ and apoptosis
🏥 not_specified 🧬 NPM1 📄 PMID: 19569254
#19069 middle Confidence
Subject: NPM1 (Nucleolar proteins)
plays_key_role_in
Object: genomic_stability (Genome stability)
Original: NPM1#plays key roles in#ribosome biogenesis/ centrosome duplication/ genomic stability/ cell cycle progression/ and apoptosis
🏥 not_specified 🧬 NPM1 📄 PMID: 19569254
#19068 middle Confidence
Subject: NPM1 (Nucleolar proteins)
plays_key_role_in
Object: centrosome_duplication (Cellular Processes)
Original: NPM1#plays key roles in#ribosome biogenesis/ centrosome duplication/ genomic stability/ cell cycle progression/ and apoptosis
🏥 not_specified 🧬 NPM1 📄 PMID: 19569254
#19067 middle Confidence
Subject: cancer_cells (Tumor cells)
become_addicted_to
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: cancer cells#become addicted to#ribosome biogenesis for protein production
🏥 not_specified 📄 PMID: 32640701
#19029 middle Confidence
Subject: epigenetic_control_disruption (Abnormal epigenetic regulation)
contributes_to
Object: cellular_transformation (Cell transformation)
Original: Aberrant ribosome biogenesis and epigenetic control disruption#contribute to#cellular transformation
🏥 not_specified 📄 PMID: 17994099
#19022 middle Confidence
Subject: nucleolus (Subcellular structure)
is_involved_in
Object: stress_response (Cellular stress response)
Original: The nucleolus#is involved in#ribosomal RNA synthesis/ ribosome biogenesis/ and stress response
🏥 not_specified 📄 PMID: 35325178
#19005 middle Confidence
Subject: ribosome_biogenesis (Molecular Process)
activates
Object: p53 (Tumor suppressor proteins)
Original: Targeting ribosome biogenesis#activates#p53 as a therapeutic strategy in human cancer
🏥 treat 🧬 TP53 📄 PMID: 36071402
#18998 middle Confidence
Subject: nucleolus (Cellular substructure)
undergoes
Object: functional_changes_in_cancer_tissues (Functionality changes)
Original: nucleolus#undergoes#morphological and functional changes in cancer tissues
🏥 Tumor dysfunction 📄 PMID: 18583314
#18997 middle Confidence
Subject: nucleolus (Cellular substructure)
undergoes
Object: morphological_changes_in_cancer_tissues (Changes in tissue morphology)
Original: nucleolus#undergoes#morphological and functional changes in cancer tissues
🏥 Tumor morphology 📄 PMID: 18583314
#18996 middle Confidence
Subject: KDM2B (Histone demethylase)
regulates
Object: ribosome_biogenesis_in_human_breast_cancer (Ribosome production)
Original: KDM2B#regulates#ribosome biogenesis in human breast cancer
🏥 Tumor Biology 🧬 KDM2B 📄 PMID: 32901907
#18681 middle Confidence
Subject: MDK (protein)
plays_a_role_in
Object: cell_proliferation (Cellular Processes)
Original: MK#plays a role in#rRNA transcription/ ribosome biogenesis/ and cell proliferation in HepG2 cells
🏥 not_specified 🧬 MDK 📄 PMID: 18985819
#18680 middle Confidence
Subject: MDK (protein)
plays_a_role_in
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: MK#plays a role in#rRNA transcription/ ribosome biogenesis/ and cell proliferation in HepG2 cells
🏥 not_specified 🧬 MDK 📄 PMID: 18985819
#18679 middle Confidence
Subject: MDK (protein)
plays_a_role_in
Object: rRNA_transcription (Transcription process)
Original: MK#plays a role in#rRNA transcription/ ribosome biogenesis/ and cell proliferation in HepG2 cells
🏥 not_specified 🧬 MDK 📄 PMID: 18985819
#17164 middle Confidence
Subject: chemotherapeutic_drugs (drug)
affect
Object: ribosome_biogenesis (Molecular Process)
Original: Chemotherapeutic drugs#induce#nucleolar stress by affecting ribosome biogenesis in nucleolus
🏥 Therapeutic significance 📄 PMID: 31183313
#17163 middle Confidence
Subject: chemotherapeutic_drugs (drug)
induce
Object: nucleolar_stress (Cellular stress)
Original: Chemotherapeutic drugs#induce#nucleolar stress by affecting ribosome biogenesis in nucleolus
🏥 Therapeutic significance 📄 PMID: 31183313
#17128 middle Confidence
Subject: SLERT_lncRNA (Long noncoding RNA)
Controls
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: SLERT lncRNA#controls#ribosome biogenesis
🏥 Ribosome biogenesis 📄 PMID: 28475895
#17127 middle Confidence
Subject: SLERT_deletion (Gene deletion)
impairs
Object: rRNA_production (Transcription product)
Original: SLERT deletion#impairs#pre-rRNA transcription and rRNA production
🏥 Ribosome biogenesis 📄 PMID: 28475895
#17126 middle Confidence
Subject: SLERT_deletion (Gene deletion)
impairs
Object: pre-rRNA_transcription (Transcription process)
Original: SLERT deletion#impairs#pre-rRNA transcription and rRNA production
🏥 Ribosome biogenesis 📄 PMID: 28475895
#17125 middle Confidence
Subject: SLERT (Long noncoding RNA)
enhances
Object: pre-rRNA_transcription (Transcription process)
Original: SLERT#enhances#pre-rRNA transcription
🏥 Ribosome biogenesis 📄 PMID: 28475895
#17123 middle Confidence
Subject: SLERT (Long noncoding RNA)
regulates
Object: DDX21_rings (Protein complex)
Original: SLERT#regulates#DDX21 rings associated with Pol I transcription
🏥 Ribosome biogenesis 🧬 DDX21 📄 PMID: 28475895
#17015 middle Confidence
Subject: NPM1 (Nucleolar proteins)
blocks
Object: increases_in_Arf(-/-)_osteoclast_activity (Cellular Processes)
Original: Knockdown of NPM#blocks#increases in Arf(-/-) ribosome output and osteoclast activity
🏥 not_specified 🧬 npm1/cdkn2a 📄 PMID: 18070929
#17014 middle Confidence
Subject: NPM1 (Nucleolar proteins)
blocks
Object: increases_in_Arf(-/-)_ribosome_output (Molecular Process)
Original: Knockdown of NPM#blocks#increases in Arf(-/-) ribosome output and osteoclast activity
🏥 not_specified 🧬 npm1/cdkn2a 📄 PMID: 18070929
#17009 middle Confidence
Subject: nucleostemin_1_knockdown (Gene expression inhibition)
impairs
Object: midgut_precursor_cell_maintenance (Stem cell maintenance process)
Original: Knockdown of nucleostemin 1#impairs#large ribosomal subunit biogenesis/ cell growth/ and midgut precursor cell maintenance
🏥 not_specified 🧬 GNL3 📄 PMID: 19710426
#17008 middle Confidence
Subject: nucleostemin_1_knockdown (Gene expression inhibition)
impairs
Object: cell_growth (Cell proliferation process)
Original: Knockdown of nucleostemin 1#impairs#large ribosomal subunit biogenesis/ cell growth/ and midgut precursor cell maintenance
🏥 not_specified 🧬 GNL3 📄 PMID: 19710426
#17007 middle Confidence
Subject: nucleostemin_1_knockdown (Gene expression inhibition)
impairs
Object: large_ribosomal_subunit_biogenesis (Ribosome biogenesis process)
Original: Knockdown of nucleostemin 1#impairs#large ribosomal subunit biogenesis/ cell growth/ and midgut precursor cell maintenance
🏥 not_specified 🧬 GNL3 📄 PMID: 19710426
#17006 middle Confidence
Subject: ARF (Tumor suppressor proteins)
restrains
Object: nucleolar_ribosome_production (Ribosome biogenesis process)
Original: ARF#restrains#nucleolar ribosome production
🏥 not_specified 🧬 CDKN2A 📄 PMID: 21937682
#17000 middle Confidence
Subject: CDKN2A (Cell cycle inhibitors)
regulates
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: ARF#regulates#ribosome biogenesis via inhibiting B23
🏥 not_specified 🧬 CDKN2A/NPM1 📄 PMID: 14636574
#16979 middle Confidence
Subject: growth_factor_signaling_pathways (signaling pathway)
activate
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: Growth-factor signaling pathways#activate#ribosome biogenesis
🏥 not_specified 📄 PMID: 33741433
#16900 middle Confidence
Subject: p14 (protein)
regulates
Object: p53_stabilization (Protein stability)
Original: p14#regulates#nucleolar stress response/ ribosome biogenesis/ and p53 stabilization
🏥 not_specified 🧬 TP53 📄 PMID: 36366533
#16899 middle Confidence
Subject: p14 (protein)
regulates
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: p14#regulates#nucleolar stress response/ ribosome biogenesis/ and p53 stabilization
🏥 not_specified 🧬 TP53 📄 PMID: 36366533
#16898 middle Confidence
Subject: p14 (protein)
regulates
Object: nucleolar_stress_response (Cellular stress process)
Original: p14#regulates#nucleolar stress response/ ribosome biogenesis/ and p53 stabilization
🏥 not_specified 🧬 TP53 📄 PMID: 36366533
#16896 middle Confidence
Subject: Nucleophosmin_1 (Ribosomal proteins)
is_involved_in
Object: genome_stability (Genome stability)
Original: Nucleophosmin 1#is involved in#ribosome biogenesis/ stress responses/ and genome stability
🏥 not_specified 🧬 NPM1 📄 PMID: 23831574
#16895 middle Confidence
Subject: Nucleophosmin_1 (Ribosomal proteins)
is_involved_in
Object: stress_responses (Cellular stress response)
Original: Nucleophosmin 1#is involved in#ribosome biogenesis/ stress responses/ and genome stability
🏥 not_specified 🧬 NPM1 📄 PMID: 23831574
#16894 middle Confidence
Subject: Nucleophosmin_1 (Ribosomal proteins)
is_involved_in
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: Nucleophosmin 1#is involved in#ribosome biogenesis/ stress responses/ and genome stability
🏥 not_specified 🧬 NPM1 📄 PMID: 23831574
#16848 middle Confidence
Subject: loss_of_ribosomal_components (Protein loss)
results_in
Object: impaired_ribosome_biogenesis (Ribosome biogenesis disorders)
Original: Impaired ribosome biogenesis#results from#disruption of rRNA biosynthesis or loss of ribosomal components
🏥 not_specified 📄 PMID: 24722283
#16847 middle Confidence
Subject: rRNA_biosynthesis_disruption (Abnormal molecular processes)
results_in
Object: impaired_ribosome_biogenesis (Ribosome biogenesis disorders)
Original: Impaired ribosome biogenesis#results from#disruption of rRNA biosynthesis or loss of ribosomal components
🏥 not_specified 📄 PMID: 24722283
#16794 middle Confidence
Subject: mislocalization_of_DDX21 (Abnormal protein localization)
leads_to
Object: reduction_in_cancer_cell_growth (Tumor cell proliferation)
Original: Mislocalization of DDX21#leads to#reduction in ribosome biogenesis and cancer cell growth
🏥 Anti-tumor mechanism 🧬 DDX21 📄 PMID: 38767454
#16793 middle Confidence
Subject: mislocalization_of_DDX21 (Abnormal protein localization)
leads_to
Object: reduction_in_ribosome_biogenesis (Ribosome biogenesis)
Original: Mislocalization of DDX21#leads to#reduction in ribosome biogenesis and cancer cell growth
🏥 Nucleolar stress 🧬 DDX21 📄 PMID: 38767454
#16791 middle Confidence
Subject: loss_of_NPM_nucleolar_localization (Abnormal subcellular localization)
leads_to
Object: loss_of_functions_in_DNA-damage_repair (Molecular Process)
Original: Loss of NPM nucleolar localization#leads to#a loss of functions in ribosome biogenesis or DNA-damage repair
🏥 not_specified 🧬 NPM1 📄 PMID: 30130654
#16790 middle Confidence
Subject: loss_of_NPM_nucleolar_localization (Abnormal subcellular localization)
leads_to
Object: loss_of_functions_in_ribosome_biogenesis (Molecular Process)
Original: Loss of NPM nucleolar localization#leads to#a loss of functions in ribosome biogenesis or DNA-damage repair
🏥 not_specified 🧬 NPM1 📄 PMID: 30130654
#16095 middle Confidence
Subject: ribosome_biogenesis (Ribosome biogenesis)
is_upregulated_during
Object: cell_growth (Cellular Processes)
Original: The cell#increases#protein synthetic capacity by upregulating ribosome biogenesis during growth
🏥 not_specified 📄 PMID: 26721423
#16094 middle Confidence
Subject: cell (cell)
increases
Object: protein_synthetic_capacity (Cellular Processes)
Original: The cell#increases#protein synthetic capacity by upregulating ribosome biogenesis during growth
🏥 not_specified 📄 PMID: 26721423
#12667 middle Confidence
Subject: nucleolus (Cellular substructure)
acts_as
Object: hub_that_traps_proteins (Functional Area)
Original: Nucleoli#act as#sites of ribosome biogenesis and hubs that trap proteins
🏥 not_specified 📄 PMID: 34884928
#12570 middle Confidence
Subject: nucleolus (Subcellular structure)
is_involved_in
Object: stress_response (Stress response)
Original: Nucleolus#is involved in#ribosome subunit biogenesis/ cell cycle control/ and stress responses
🏥 not_specified 📄 PMID: 16819967
#12436 middle Confidence
Subject: DDX5 (RNA helicase)
is_a_target_of
Object: ARF_tumor_suppressor (Tumor suppressor proteins)
Original: DDX5#is a target of#ARF tumor suppressor
🏥 not_specified 🧬 DDX5/CDKN2A 📄 PMID: 21937682
#12392 middle Confidence
Subject: B23.1 (Nucleolar protein isoforms)
expression_is_correlated_with
Object: ribosome_biogenesis (Ribosome)
Original: B23.1 expression#is correlated with#proliferation rate and ribosome biogenesis
🏥 not_specified 🧬 B23 📄 PMID: 8287070
#12391 middle Confidence
Subject: B23.1 (Nucleolar protein isoforms)
expression_is_correlated_with
Object: proliferation_rate (Cell proliferation rate)
Original: B23.1 expression#is correlated with#proliferation rate and ribosome biogenesis
🏥 not_specified 🧬 B23 📄 PMID: 8287070
#12362 middle Confidence
Subject: Acr (Small molecule compounds)
impairs
Object: polysome_formation (Molecular complex assembly)
Original: Acr#impairs#ribosome biogenesis and polysome formation
🏥 not_specified 📄 PMID: 27741518
#12361 middle Confidence
Subject: Acr (Small molecule compounds)
impairs
Object: ribosome_biogenesis (Molecular complex assembly)
Original: Acr#impairs#ribosome biogenesis and polysome formation
🏥 not_specified 📄 PMID: 27741518
#12281 middle Confidence
Subject: p53 (Transcription Factors)
Controls
Object: cell_cycle_progression (Cellular Processes)
Original: pRb and p53#control#ribosome biogenesis and cell cycle progression
🏥 not_specified 🧬 RB1/TP53 📄 PMID: 15557214
#12280 middle Confidence
Subject: p53 (Transcription Factors)
Controls
Object: ribosome_biogenesis (Molecular complex formation process)
Original: pRb and p53#control#ribosome biogenesis and cell cycle progression
🏥 not_specified 🧬 RB1/TP53 📄 PMID: 15557214
#12279 middle Confidence
Subject: PcqI (Cell cycle regulatory proteins)
Controls
Object: cell_cycle_progression (Cellular Processes)
Original: pRb and p53#control#ribosome biogenesis and cell cycle progression
🏥 not_specified 🧬 RB1/TP53 📄 PMID: 15557214
#12278 middle Confidence
Subject: PcqI (Cell cycle regulatory proteins)
Controls
Object: ribosome_biogenesis (Molecular complex formation process)
Original: pRb and p53#control#ribosome biogenesis and cell cycle progression
🏥 not_specified 🧬 RB1/TP53 📄 PMID: 15557214
#11505 middle Confidence
Subject: ribosome_biogenesis (Molecular Biology Process)
comprises
Object: processing_of_ribosomal_RNA (Molecular Processing)
Original: Ribosome biogenesis#comprises#transcription/ modification/ and processing of ribosomal RNA
🏥 not_specified 📄 PMID: 20498634
#11504 middle Confidence
Subject: ribosome_biogenesis (Molecular Biology Process)
comprises
Object: modification_of_ribosomal_RNA (Molecular modification)
Original: Ribosome biogenesis#comprises#transcription/ modification/ and processing of ribosomal RNA
🏥 not_specified 📄 PMID: 20498634
#11503 middle Confidence
Subject: ribosome_biogenesis (Molecular Biology Process)
comprises
Object: transcription_of_ribosomal_RNA (Transcription process)
Original: Ribosome biogenesis#comprises#transcription/ modification/ and processing of ribosomal RNA
🏥 not_specified 📄 PMID: 20498634
#10776 middle Confidence
Subject: aberrant_ribosome_biogenesis (Abnormal ribosome biogenesis)
correlates_with
Object: enhanced_translation (Increased protein synthesis)
Original: Increased nucleolar size and activity#correlate with#aberrant ribosome biogenesis and enhanced translation in cancer cells
🏥 Cancer related 📄 PMID: 37851577
#10775 middle Confidence
Subject: nucleolar_size_and_activity (Nucleolus structure and function)
correlates_with
Object: aberrant_ribosome_biogenesis (Abnormal ribosome biogenesis)
Original: Increased nucleolar size and activity#correlate with#aberrant ribosome biogenesis and enhanced translation in cancer cells
🏥 Cancer related 📄 PMID: 37851577
#10707 middle Confidence
Subject: ZNF692 (Transcription Factors)
forms
Object: hub_with_ribosome_biogenesis_factors (Protein complex)
Original: ZNF692#forms#a hub with exosome complex and ribosome biogenesis factors
🏥 not_specified 🧬 ZNF692 📄 PMID: 37851577
#10706 middle Confidence
Subject: ZNF692 (Transcription Factors)
forms
Object: hub_with_exosome_complex (Protein complex)
Original: ZNF692#forms#a hub with exosome complex and ribosome biogenesis factors
🏥 not_specified 🧬 ZNF692 📄 PMID: 37851577
#10600 middle Confidence
Subject: AgNOR_positive_response (Molecular detection signal)
is_related_to
Object: cellular_demand_for_ribosome_biogenesis (Ribosome biogenesis requirements)
Original: AgNOR positive response#is related to#cellular demand for ribosome biogenesis
🏥 not_specified 📄 PMID: 18160100
#6633 middle Confidence
Subject: ribosome_biogenesis (Cellular Processes)
requires
Object: trans-acting_factors (Protein complex)
Original: Ribosome biogenesis#requires#a vast number of trans-acting factors
🏥 not_specified 📄 PMID: 12655004
#6549 middle Confidence
Subject: ribosome_biogenesis (Ribosome biogenesis)
includes
Object: ribosomal_protein_biosynthesis (Molecular Process)
Original: Ribosome biogenesis#includes#making and processing of ribosomal RNAs and biosynthesis of ribosomal proteins
🏥 not_specified 📄 PMID: 30706966
#6548 middle Confidence
Subject: ribosome_biogenesis (Ribosome biogenesis)
includes
Object: ribosomal_RNA_processing (Molecular Process)
Original: Ribosome biogenesis#includes#making and processing of ribosomal RNAs and biosynthesis of ribosomal proteins
🏥 not_specified 📄 PMID: 30706966
#6528 middle Confidence
Subject: Nuclear_export_of_ribosomes (Molecular Process)
is_increased_in
Object: absence_of_ARF (Gene deletion status)
Original: Transcription of rDNA/ processing of rRNA/ and nuclear export of ribosomes#are increased in#absence of ARF
🏥 not_specified 🧬 CDKN2A 📄 PMID: 18070929
#6527 middle Confidence
Subject: Processing_of_rRNA (Molecular Process)
is_increased_in
Object: absence_of_ARF (Gene deletion status)
Original: Transcription of rDNA/ processing of rRNA/ and nuclear export of ribosomes#are increased in#absence of ARF
🏥 not_specified 🧬 CDKN2A 📄 PMID: 18070929
#6526 middle Confidence
Subject: Transcription_of_rDNA (Molecular Process)
is_increased_in
Object: absence_of_ARF (Gene deletion status)
Original: Transcription of rDNA/ processing of rRNA/ and nuclear export of ribosomes#are increased in#absence of ARF
🏥 not_specified 🧬 CDKN2A 📄 PMID: 18070929
#6525 middle Confidence
Subject: Protein_synthesis (Molecular Process)
is_elevated_in
Object: absence_of_ARF (Gene deletion status)
Original: Ribosome biogenesis and protein synthesis#are elevated in#absence of ARF
🏥 not_specified 🧬 CDKN2A 📄 PMID: 18070929
#6524 middle Confidence
Subject: Ribosome_biogenesis (Molecular Process)
is_elevated_in
Object: absence_of_ARF (Gene deletion status)
Original: Ribosome biogenesis and protein synthesis#are elevated in#absence of ARF
🏥 not_specified 🧬 CDKN2A 📄 PMID: 18070929
#6372 middle Confidence
Subject: nucleoli (Subcellular structure)
are_not_limited_to
Object: ribosome_biogenesis (Molecular complex)
Original: Nucleoli#are not limited to#ribosome biogenesis
🏥 not_specified 📄 PMID: 38642633
#5088 middle Confidence
Subject: AgNOR_expression (Nucleolar organizer region-associated substance)
is_related_to
Object: ribosome_biogenesis_rate (Ribosome biogenesis)
Original: AgNOR expression#is related to#ribosome biogenesis rate
🏥 not_specified 📄 PMID: 15220371