Search results of triples
A total of 68 records found
#22199
high Confidence
Subject:
nucleolus
(Organelles)
→
is
→
Object:
subnuclear_compartment
(Subcellular structure)
Original: nucleolus#is#a subnuclear compartment with key roles in rRNA synthesis and ribosome biogenesis
#22006
high Confidence
Subject:
nucleolus
(Organelles)
→
plays_key_role_in
→
Object:
ribosome_biogenesis
(Molecular Process)
Original: nucleolus#is#a subnuclear compartment with key roles in rRNA synthesis and ribosome biogenesis
#22005
high Confidence
Subject:
nucleolus
(Organelles)
→
plays_key_role_in
→
Object:
rRNA_synthesis
(Molecular Process)
Original: nucleolus#is#a subnuclear compartment with key roles in rRNA synthesis and ribosome biogenesis
#21617
high Confidence
Subject:
cellular_senescence
(Cellular Processes)
→
reduces
→
Object:
nucleolar_rRNA_synthesis
(Molecular Process)
Original: Cellular senescence#reduces#nucleolar rRNA synthesis and maturation
#21550
high Confidence
Subject:
Actinomycin_D
(Antibiotics)
→
inhibits
→
Object:
rRNA_synthesis
(Molecular Process)
Original: Actinomycin D#inhibits#rRNA synthesis
#20469
high Confidence
Subject:
guanine_nucleotide
(Small molecule metabolites)
→
depletion_by
→
Object:
AVN-944
(Chemotherapy drugs)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#a reduction in levels of 45S precursor rRNA synthesis
#20468
high Confidence
Subject:
guanine_nucleotide
(Small molecule metabolites)
→
depletion_by
→
Object:
MPA
(Chemotherapy drugs)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#a reduction in levels of 45S precursor rRNA synthesis
#20438
high Confidence
Subject:
TIF-IA
(Transcription Factors)
→
mediates
→
Object:
rRNA_synthesis
(RNA synthesis process)
Original: Growth-dependent regulation of rRNA synthesis#is mediated by#TIF-IA
#20432
high Confidence
Subject:
Oxaliplatin
(Chemotherapy drugs)
→
inhibits
→
Object:
rRNA_synthesis_by_POLR1
(Transcription process)
Original: Oxaliplatin#significantly inhibits#rRNA synthesis by Pol I
#20360
high Confidence
Subject:
Actinomycin_D
(Chemotherapy drugs)
→
induces
→
Object:
reorganization_of_nucleolar_components
(Subcellular structural changes)
Original: Actinomycin D (AMD)#induces#reorganization of nucleolar components by inhibiting rRNA synthesis
#20075
high Confidence
Subject:
guanine_nucleotide
(Small molecule metabolites)
→
depletion
→
Object:
45S_precursor_rRNA_synthesis
(rRNA transcription synthesis)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#a reduction in levels of 45S precursor rRNA synthesis
#19161
middle Confidence
Subject:
Dysregulated_rRNA_synthesis_by_Pol_I
(Transcription abnormalities)
→
is_associated_with
→
Object:
uncontrolled_cell_proliferation
(Cellular Processes)
Original: Dysregulated rRNA synthesis by Pol I#is associated with#uncontrolled cell proliferation
#19114
middle Confidence
Subject:
rRNA_synthesis_perturbation
(Molecular Process)
→
is_related_to
→
Object:
tumor_progression
(Tumor progression)
Original: Perturbations of rRNA synthesis#are related to#cell proliferation and tumor progression
#19113
middle Confidence
Subject:
rRNA_synthesis_perturbation
(Molecular Process)
→
is_related_to
→
Object:
cell_proliferation
(Cell proliferation)
Original: Perturbations of rRNA synthesis#are related to#cell proliferation and tumor progression
#19102
middle Confidence
Subject:
GSK3B
(Protein kinase)
→
inhibition_upregulates
→
Object:
28S_rRNA_synthesis
(Ribosomal RNA synthesis)
Original: GSK3beta inhibition#upregulated#45S/ 18S and 28S rRNA synthesis
#19101
middle Confidence
Subject:
GSK3B
(Protein kinase)
→
inhibition_upregulates
→
Object:
18S_rRNA_synthesis
(Ribosomal RNA synthesis)
Original: GSK3beta inhibition#upregulated#45S/ 18S and 28S rRNA synthesis
#19100
middle Confidence
Subject:
GSK3B
(Protein kinase)
→
inhibition_upregulates
→
Object:
45S_rRNA_synthesis
(Ribosomal RNA synthesis)
Original: GSK3beta inhibition#upregulated#45S/ 18S and 28S rRNA synthesis
#19091
middle Confidence
Subject:
Rapamycin
(Inhibitor drugs)
→
impairs
→
Object:
synthesis_of_5S_rRNA
(rRNA synthesis)
Original: Rapamycin#impairs#synthesis of 18S/ 28S/ and 5S rRNA
#19090
middle Confidence
Subject:
Rapamycin
(Inhibitor drugs)
→
impairs
→
Object:
synthesis_of_28S_rRNA
(rRNA synthesis)
Original: Rapamycin#impairs#synthesis of 18S/ 28S/ and 5S rRNA
#19089
middle Confidence
Subject:
Rapamycin
(Inhibitor drugs)
→
impairs
→
Object:
synthesis_of_18S_rRNA
(rRNA synthesis)
Original: Rapamycin#impairs#synthesis of 18S/ 28S/ and 5S rRNA
#19050
middle Confidence
Subject:
UBF1-mediated_ECT2_recruitment
(Protein complex assembly)
→
elevates
→
Object:
rRNA_synthesis
(Transcription product)
Original: UBF1-mediated ECT2 recruitment#elevates#rRNA synthesis
#19025
middle Confidence
Subject:
pKi-67-CALI
(Optogenetics Tools)
→
resulted_in
→
Object:
inhibition_of_RNA_polymerase_I-dependent_nucleolar_rRNA_synthesis
(Transcriptional repression)
Original: pKi-67-CALI#resulted in#inhibition of RNA polymerase I-dependent nucleolar rRNA synthesis
#19012
middle Confidence
Subject:
nucleolar_lncRNAs
(Long noncoding RNA)
→
ensure
→
Object:
cessation_of_rRNA_synthesis_during_stress
(Transcriptional regulatory events)
Original: Nucleolar lncRNAs#ensure#cessation of rRNA synthesis during stress adaptation
#18995
middle Confidence
Subject:
rRNA_synthesis
(rRNA synthesis)
→
is_controlled_by
→
Object:
epigenetic_regulation_of_chromatin_condensation
(Epigenetic regulation)
Original: rRNA synthesis#is controlled by#epigenetic regulation of chromatin condensation
#17177
middle Confidence
Subject:
rRNA_methylases
(Enzymes)
→
are_regulated_by
→
Object:
cellular_metabolites
(Metabolites)
Original: rRNA methylases#are regulated by#cellular metabolites during nucleolar biosynthesis
#17075
middle Confidence
Subject:
DHX33_K94R_mutant
(DEAD/DEAH-box helicase mutants)
→
inhibits
→
Object:
endogenous_rRNA_synthesis
(rRNA synthesis)
Original: NTPase-defective DHX33 mutant (K94R)#inhibited#endogenous rRNA synthesis
#17074
middle Confidence
Subject:
DHX33
(DEAD/DEAH-box helicase)
→
overexpression_enhances
→
Object:
47S_rRNA_synthesis
(rRNA synthesis)
Original: Wild-type DHX33 overexpression#enhanced#47S rRNA synthesis
#17073
middle Confidence
Subject:
DHX33
(DEAD/DEAH-box helicase)
→
knockdown_decreases
→
Object:
rRNA_synthesis
(rRNA synthesis)
Original: DHX33 knockdown#decreased#association of Pol I with rDNA and rRNA synthesis
#17072
middle Confidence
Subject:
DHX33
(DEAD/DEAH-box helicase)
→
knockdown_decreases
→
Object:
Pol_I_association_with_rDNA
(Molecular complex)
Original: DHX33 knockdown#decreased#association of Pol I with rDNA and rRNA synthesis
#17020
middle Confidence
Subject:
POLR1A
(RNA polymerase I subunit)
→
downregulation_inactivates
→
Object:
MDM2-mediated_p53_degradation
(Protein degradation process)
Original: Downregulation of rRNA synthesis#inactivates#MDM2-mediated p53 degradation
#17019
middle Confidence
Subject:
POLR1A
(RNA polymerase I subunit)
→
downregulation_stabilises
→
Object:
TP53
(Transcription Factors)
Original: Downregulation of rRNA synthesis#stabilises#p53
#16848
middle Confidence
Subject:
loss_of_ribosomal_components
(Protein loss)
→
results_in
→
Object:
impaired_ribosome_biogenesis
(Ribosome biogenesis disorders)
Original: Impaired ribosome biogenesis#results from#disruption of rRNA biosynthesis or loss of ribosomal components
#16847
middle Confidence
Subject:
rRNA_biosynthesis_disruption
(Abnormal molecular processes)
→
results_in
→
Object:
impaired_ribosome_biogenesis
(Ribosome biogenesis disorders)
Original: Impaired ribosome biogenesis#results from#disruption of rRNA biosynthesis or loss of ribosomal components
#16831
middle Confidence
Subject:
tumor_suppressors
(Tumor suppressor proteins)
→
interfere_with
→
Object:
rRNA_synthesis
(rRNA synthesis)
Original: Oncogenic proteins and tumor suppressors#target#RNA polymerase I and interfere with rRNA synthesis
#16830
middle Confidence
Subject:
oncogenic_proteins
(Oncogenic proteins)
→
interfere_with
→
Object:
rRNA_synthesis
(rRNA synthesis)
Original: Oncogenic proteins and tumor suppressors#target#RNA polymerase I and interfere with rRNA synthesis
#16829
middle Confidence
Subject:
tumor_suppressors
(Tumor suppressor proteins)
→
target
→
Object:
RNA_polymerase_I
(Transcriptase)
Original: Oncogenic proteins and tumor suppressors#target#RNA polymerase I and interfere with rRNA synthesis
#16828
middle Confidence
Subject:
oncogenic_proteins
(Oncogenic proteins)
→
target
→
Object:
RNA_polymerase_I
(Transcriptase)
Original: Oncogenic proteins and tumor suppressors#target#RNA polymerase I and interfere with rRNA synthesis
#16800
middle Confidence
Subject:
neuregulin_1
(Ligand protein)
→
increases
→
Object:
pre-rRNA_synthesis
(Molecular synthesis process)
Original: Neuregulin 1#increases#pre-rRNA synthesis
#16768
middle Confidence
Subject:
SUN1
(Nuclear membrane protein)
→
depletion_causes
→
Object:
reduced_rRNA_synthesis
(rRNA synthesis)
Original: Depletion of SUN1#causes#nucleolar hypertrophy and reduced rRNA synthesis
#16767
middle Confidence
Subject:
SUN1
(Nuclear membrane protein)
→
depletion_causes
→
Object:
nucleolar_hypertrophy
(Cellular substructure phenotype)
Original: Depletion of SUN1#causes#nucleolar hypertrophy and reduced rRNA synthesis
#16754
middle Confidence
Subject:
NOLC1
(Nucleolar proteins)
→
is_responsible_for
→
Object:
chaperone_shuttling
(Molecular modification regulation)
Original: NOLC1#is responsible for#nucleolus construction and rRNA synthesis/ as well as chaperone shuttling between the nucleolus and cytoplasm
#16753
middle Confidence
Subject:
NOLC1
(Nucleolar proteins)
→
is_responsible_for
→
Object:
rRNA_synthesis
(Molecular modification regulation)
Original: NOLC1#is responsible for#nucleolus construction and rRNA synthesis/ as well as chaperone shuttling between the nucleolus and cytoplasm
#16752
middle Confidence
Subject:
NOLC1
(Nucleolar proteins)
→
is_responsible_for
→
Object:
nucleolus_construction
(Molecular complex)
Original: NOLC1#is responsible for#nucleolus construction and rRNA synthesis/ as well as chaperone shuttling between the nucleolus and cytoplasm
#12636
middle Confidence
Subject:
inhibition_of_rRNA_synthesis
(Molecular Process)
→
induces
→
Object:
p53_activation
(Protein activation)
Original: Inhibition of rRNA synthesis#induces#nucleoplasmic translocation of NPM1 and p53 activation
#12635
middle Confidence
Subject:
inhibition_of_rRNA_synthesis
(Molecular Process)
→
induces
→
Object:
nucleoplasmic_translocation_of_NPM1
(Cellular Processes)
Original: Inhibition of rRNA synthesis#induces#nucleoplasmic translocation of NPM1 and p53 activation
#12566
middle Confidence
Subject:
Protein_B23
(Nucleolus-associated protein)
→
translocates_to
→
Object:
nucleoplasm
(Cellular substructure)
Original: Protein B23#translocates to#nucleoplasm due to lack of rRNA synthesis
#12543
middle Confidence
Subject:
dFLCN_downregulation
(Down-regulation of gene expression)
→
upregulates
→
Object:
rRNA_synthesis
(rRNA synthesis)
Original: dFLCN downregulation#results in#an increase in nucleolar volume and upregulation of rRNA synthesis
#12542
middle Confidence
Subject:
dFLCN_downregulation
(Down-regulation of gene expression)
→
results_in
→
Object:
increase_in_nucleolar_volume
(Organelle phenotype)
Original: dFLCN downregulation#results in#an increase in nucleolar volume and upregulation of rRNA synthesis
#12500
middle Confidence
Subject:
acidosis
(Environmental factors)
→
decreases
→
Object:
Precursor_rRNA_synthesis
(Molecular Process)
Original: Acidosis#decreases#precursor rRNA synthesis
#12498
middle Confidence
Subject:
cellular_senescence
(Cellular Processes)
→
reduces
→
Object:
nucleolar_rRNA_maturation
(Molecular Process)
Original: Cellular senescence#reduces#nucleolar rRNA synthesis and maturation
#12390
middle Confidence
Subject:
NMD3
(Nuclear export adaptor protein)
→
couples
→
Object:
rRNA_processing_pathway
(rRNA processing pathway)
Original: CRM1 and NMD3#couple#rRNA synthesis and processing pathways
#12389
middle Confidence
Subject:
CRM1
(Nuclear export receptor protein)
→
couples
→
Object:
rRNA_synthesis_pathway
(rRNA synthesis pathway)
Original: CRM1 and NMD3#couple#rRNA synthesis and processing pathways
#12360
middle Confidence
Subject:
Acr
(Chemical drugs)
→
inhibits
→
Object:
rRNA_synthesis
(rRNA synthesis)
Original: Acr#inhibits#rRNA synthesis
#12348
middle Confidence
Subject:
Phytochemicals
(Plant active small molecules)
→
downregulate
→
Object:
RPS6_phosphorylation
(Protein phosphorylation)
Original: phytochemicals#decrease#NOP2/ proliferation-associated nucleolar protein p120/ WDR12/ and phosphorylation of S6 ribosomal protein
#12347
middle Confidence
Subject:
Phytochemicals
(Plant active small molecules)
→
downregulate
→
Object:
WDR12
(Ribosomal proteins)
Original: phytochemicals#decrease#NOP2/ proliferation-associated nucleolar protein p120/ WDR12/ and phosphorylation of S6 ribosomal protein
#12346
middle Confidence
Subject:
Phytochemicals
(Plant active small molecules)
→
downregulate
→
Object:
NOP2
(Ribosomal proteins)
Original: phytochemicals#decrease#NOP2/ proliferation-associated nucleolar protein p120/ WDR12/ and phosphorylation of S6 ribosomal protein
#12283
middle Confidence
Subject:
p53
(Transcription Factors)
→
upregulates
→
Object:
rRNA_synthesis
(Molecular modification regulation)
Original: Altered pRb and p53 function#upregulates#rRNA synthesis
#12282
middle Confidence
Subject:
PcqI
(Cell cycle regulatory proteins)
→
upregulates
→
Object:
rRNA_synthesis
(Molecular modification regulation)
Original: Altered pRb and p53 function#upregulates#rRNA synthesis
#12276
middle Confidence
Subject:
Nucleolar_organizer_regions
(Chromosome domain)
→
are_interpreted_as
→
Object:
sites_of_rRNA_synthesis_resumption
(Functional site)
Original: Nucleolar organizer regions#are interpreted as#sites where rRNA synthesis resumes
#12131
middle Confidence
Subject:
interphase_AgNORs
(Nucleolus-related organic silver reactants)
→
contain
→
Object:
rRNA_synthesis_components
(Ribosomal RNA synthesis components)
Original: Interphase AgNORs#contain#components necessary for rRNA synthesis
#10138
middle Confidence
Subject:
RPS6
(Ribosomal proteins)
→
follows
→
Object:
O-GlcNAcylation_dynamics
(Protein modification)
Original: RPS6#follows#different dynamics of O-GlcNAcylation than nutrient-induced phosphorylation
#6670
middle Confidence
Subject:
Norethindrone
(Synthetic hormones)
→
interferes_with
→
Object:
rRNA_synthesis
(Transcription process)
Original: Norethindrone#interferes with#rRNA synthesis during intranucleolar DNA duplication
#6482
middle Confidence
Subject:
nucleolar_stress
(Cellular stress response)
→
is_shown_by
→
Object:
upregulation_of_p27kip1
(Cell cycle regulatory proteins)
Original: Nucleolar stress#is shown by#decreased nascent pre-rRNA synthesis/ fibrillarin perinucleolar cap formation/ and upregulation of p27kip1
#6481
middle Confidence
Subject:
nucleolar_stress
(Cellular stress response)
→
is_shown_by
→
Object:
fibrillarin_perinucleolar_cap_formation
(Changes in nucleolar structure)
Original: Nucleolar stress#is shown by#decreased nascent pre-rRNA synthesis/ fibrillarin perinucleolar cap formation/ and upregulation of p27kip1
#6480
middle Confidence
Subject:
nucleolar_stress
(Cellular stress response)
→
is_shown_by
→
Object:
decreased_nascent_pre-rRNA_synthesis
(rRNA synthesis)
Original: Nucleolar stress#is shown by#decreased nascent pre-rRNA synthesis/ fibrillarin perinucleolar cap formation/ and upregulation of p27kip1
#6416
middle Confidence
Subject:
NAT10_acetylation_status
(Protein modification status)
→
Controls
→
Object:
autophagy
(Cellular Processes)
Original: Acetylation status of NAT10#controls#rRNA synthesis and autophagy in response to energy stress
#6415
middle Confidence
Subject:
NAT10_acetylation_status
(Protein modification status)
→
Controls
→
Object:
rRNA_synthesis
(Molecular synthesis process)
Original: Acetylation status of NAT10#controls#rRNA synthesis and autophagy in response to energy stress
#4771
middle Confidence
Subject:
Ag-NOR_proteins
(Nucleolus-associated protein)
→
affect
→
Object:
ribosomal_gene_structure
(Genome structure)
Original: Ag-NOR proteins#affect#ribosomal gene structure rather than rRNA synthesis