Search results of triples
A total of 165 records found
#22128
high Confidence
Subject:
NPM1_mutation
(Gene mutation)
→
is_regarded_as
→
Object:
distinct_genetic_entity_in_WHO_classification
(Molecular typing)
Original: NPM1 mutation#is regarded as#a distinct genetic entity in the WHO classification of hematopoietic malignancies
#22114
high Confidence
Subject:
TP53
(Tumor suppressor genes)
→
is_involved_in
→
Object:
tumor_suppression
(Tumor suppressor function)
Original: GLTSCR2#is involved in#tumor suppression with p53/ NPM/ and MYC
#21840
high Confidence
Subject:
RT-PCR
(Molecular detection technology)
→
indicated
→
Object:
fusion_gene_product_of_NPM1
(Fusion gene product)
Original: RT-PCR#indicated#fusion gene product of ALK and nucleophosmin
#21839
high Confidence
Subject:
RT-PCR
(Molecular detection technology)
→
indicated
→
Object:
fusion_gene_product_of_ALK
(Fusion gene product)
Original: RT-PCR#indicated#fusion gene product of ALK and nucleophosmin
#21662
high Confidence
Subject:
Nucleophosmin_1
(Nucleolar proteins)
→
is_located_in
→
Object:
nucleolus
(Subcellular structure)
Original: Nucleophosmin 1 (NPM1)#is predominantly located in#the nucleolus
#21652
high Confidence
Subject:
NPM1
(Nucleolar proteins)
→
facilitates
→
Object:
ribosome_biogenesis
(Molecular complex synthesis)
Original: NPM1#facilitates#ribosome biogenesis and nucleolar stress responses
#21640
high Confidence
Subject:
NPM1
(Protein coding genes)
→
mutated_leads_to
→
Object:
aberrant_cytoplasmic_dislocation_of_NPM-c
(Abnormal protein localization)
Original: Mutations in NPM1#lead to#aberrant cytoplasmic dislocation of NPM-c
#21636
high Confidence
Subject:
NPM1c+_variant
(Protein coding gene mutants)
→
causes
→
Object:
cytoplasmic_accumulation_of_APE1
(Abnormal molecular localization)
Original: Expression of NPM1c+ variant#causes#cytoplasmic accumulation of APE1 in HeLa cells/ OCI/AML3 cells/ and primary lymphoblasts
#20569
high Confidence
Subject:
NPM1_gene
(Protein coding genes)
→
is_mutated_in
→
Object:
Leukemia
(Tumor phenotype)
Original: NPM1 gene#is translocated or mutated in#lymphomas and leukemias
#20568
high Confidence
Subject:
NPM1_gene
(Protein coding genes)
→
is_translocated_in
→
Object:
lymphoma
(Tumor phenotype)
Original: NPM1 gene#is translocated or mutated in#lymphomas and leukemias
#20517
high Confidence
Subject:
NPM1
(Nucleolar phosphoprotein)
→
is_mutated_in
→
Object:
AML_patients
(patient)
Original: NPM#is mutated in#one third of AML patients
#20511
high Confidence
Subject:
NPM1
(Protein coding genes)
→
is_mutated_in
→
Object:
NPM1c+_AML_cells
(Tumor cells)
Original: Cytoplasmic accumulation of APE1#is associated with#NPM1c+ AML and other cancers
#20455
high Confidence
Subject:
NPM1
(Protein coding genes)
→
is_critical_in
→
Object:
ribosome_biogenesis
(Ribosome biogenesis)
Original: Nucleophosmin (NPM)#is critical in#ribosome biogenesis
#20448
high Confidence
Subject:
TP53
(Tumor suppressor genes)
→
is_involved_in
→
Object:
oncogenesis
(Tumorigenesis)
Original: GLTSCR2#is involved in#oncogenesis with p53/ NPM/ and MYC
#20428
high Confidence
Subject:
NPM1
(Nucleolar proteins)
→
plays_key_role_in
→
Object:
ribosome_biogenesis
(Ribosome biogenesis)
Original: NPM1#plays key roles in#ribosome biogenesis/ centrosome duplication/ genomic stability/ cell cycle progression/ and apoptosis
#20399
high Confidence
Subject:
NPM1
(Protein coding genes)
→
leads_to
→
Object:
aberrant_cytoplasmic_localization
(Subcellular localization)
Original: Mutations in NPM1#lead to#aberrant cytoplasmic localization in AML
#20398
high Confidence
Subject:
NPM1
(Protein coding genes)
→
mutated_in
→
Object:
AML
(disease)
Original: Mutations in NPM1#lead to#aberrant cytoplasmic localization in AML
#20378
high Confidence
Subject:
NPM
(Ribosomal proteins)
→
is_mislocalized_to
→
Object:
Cytoplasm
(Subcellular structure)
Original: Mutations#cause#aberrant cytoplasmic localization of NPM
#20092
high Confidence
Subject:
Nucleophosmin_1
(Nucleolar proteins)
→
regulates
→
Object:
ribosome_biogenesis
(Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
#20091
high Confidence
Subject:
Nucleophosmin_1
(Nucleolar proteins)
→
regulates
→
Object:
centrosome_duplication
(Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
#20085
high Confidence
Subject:
NPM1
(Protein coding genes)
→
is_associated_with
→
Object:
cytoplasmic_localization_in_AML
(Abnormal molecular localization)
Original: One-third of acute myeloid leukemias (AMLs)#are associated with#aberrant localization of NPM1 to the cytoplasm (NPM1c+)
#20072
high Confidence
Subject:
NPM1
(Protein coding genes)
→
is_overexpressed_in
→
Object:
tumor
(Tumor phenotype)
Original: Nucleophosmin (NPM)#is found overexpressed in#many types of tumors
#20000
high Confidence
Subject:
Nucleophosmin_1
(Nucleolar proteins)
→
regulates
→
Object:
nucleolar_stress_response
(Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
#19918
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
facilitates
→
Object:
nucleolar_stress_response
(Cellular stress response)
Original: NPM1#facilitates#ribosome biogenesis and nucleolar stress responses
#19911
middle Confidence
Subject:
NPM1
(Protein coding genes)
→
contributes_to
→
Object:
NPM1c+_tumorigenesis
(Tumorigenesis)
Original: NPM1#has#indirect but significant role in BER and NPM1c+ tumorigenesis
#19907
middle Confidence
Subject:
NPM1
(Protein coding genes)
→
is_linked_to
→
Object:
APE1_functional_activation
(Protease activation)
Original: NPM1 expression#is linked to#functional activation of APE1
#19880
middle Confidence
Subject:
NPM1-FBW7_interaction
(Protein complex)
→
acts_as
→
Object:
tumor_suppressor_mechanism
(Tumor suppressor mechanism)
Original: NPM-Fbw7 interaction#acts as#a central tumor suppressor mechanism
#19872
middle Confidence
Subject:
Deguelin
(Small molecule drugs)
→
downregulates
→
Object:
NPM1_mutant_protein
(Mutant protein)
Original: Deguelin#down-regulated#NPM1 mutant protein
#19147
middle Confidence
Subject:
NPM1
(Protein coding genes)
→
plays_role_in
→
Object:
BER_pathway
(DNA repair pathways)
Original: NPM1#has#indirect but significant role in BER and NPM1c+ tumorigenesis
#19146
middle Confidence
Subject:
APE1
(DNA repair enzymes)
→
accumulates_in
→
Object:
Cytoplasm
(Subcellular structure)
Original: Expression of NPM1c+ variant#causes#cytoplasmic accumulation of APE1 in HeLa cells/ OCI/AML3 cells/ and primary lymphoblasts
#19145
middle Confidence
Subject:
APE1
(DNA repair enzymes)
→
accumulates_in
→
Object:
NPM1c+_AML_cells
(Tumor cells)
Original: Cytoplasmic accumulation of APE1#is associated with#NPM1c+ AML and other cancers
#19088
middle Confidence
Subject:
ZNF692
(Transcription Factors)
→
produces
→
Object:
irregular_condensates
(Phase separation structure)
Original: NPM1 mixed with ZNF692#produces#irregular condensates resembling living cell nucleoli
#19087
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
produces
→
Object:
irregular_condensates
(Phase separation structure)
Original: NPM1 mixed with ZNF692#produces#irregular condensates resembling living cell nucleoli
#19086
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
forms
→
Object:
spherical_condensates
(Phase separation structure)
Original: Purified NPM1#forms#spherical condensates in vitro
#19071
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
plays_key_role_in
→
Object:
apoptosis
(Apoptosis)
Original: NPM1#plays key roles in#ribosome biogenesis/ centrosome duplication/ genomic stability/ cell cycle progression/ and apoptosis
#19070
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
plays_key_role_in
→
Object:
cell_cycle_progression
(Cell cycle progression)
Original: NPM1#plays key roles in#ribosome biogenesis/ centrosome duplication/ genomic stability/ cell cycle progression/ and apoptosis
#19069
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
plays_key_role_in
→
Object:
genomic_stability
(Genome stability)
Original: NPM1#plays key roles in#ribosome biogenesis/ centrosome duplication/ genomic stability/ cell cycle progression/ and apoptosis
#19068
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
plays_key_role_in
→
Object:
centrosome_duplication
(Cellular Processes)
Original: NPM1#plays key roles in#ribosome biogenesis/ centrosome duplication/ genomic stability/ cell cycle progression/ and apoptosis
#19057
middle Confidence
Subject:
SNORA51
(Noncoding RNA)
→
increases
→
Object:
c-MYC expression
(Transcription factor expression)
Original: SNORA51#increases#c-MYC expression
#19056
middle Confidence
Subject:
SNORA51
(Noncoding RNA)
→
induces_changes_in
→
Object:
NPM1 expression
(Nucleolar protein expression)
Original: SNORA51#induces changes in#NPM1 expression
#19055
middle Confidence
Subject:
SNORA51
(Noncoding RNA)
→
reduces
→
Object:
RPL3 expression
(Ribosomal protein expression)
Original: SNORA51#reduces#nucleolar RPL3 expression
#18867
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
differs_significantly_depending_on
→
Object:
receptor_status
(Receptor status)
Original: NPM parameters#differ significantly depending on#Ki-67 and p53 expression levels and receptor status of leiomyosarcoma
#18866
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
differs_significantly_depending_on
→
Object:
TP53_expression_level
(Tumor suppressor proteins)
Original: NPM parameters#differ significantly depending on#Ki-67 and p53 expression levels and receptor status of leiomyosarcoma
#18865
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
differs_significantly_depending_on
→
Object:
Ki-67_expression_level
(Cell proliferation markers)
Original: NPM parameters#differ significantly depending on#Ki-67 and p53 expression levels and receptor status of leiomyosarcoma
#17220
middle Confidence
Subject:
Doxorubicin
(Chemotherapy drugs)
→
inhibits
→
Object:
cell_growth
(Cell proliferation)
Original: DOX#induces#nucleophosmin translocation from the nucleolus to nucleoplasm and inhibits cell growth in a time- and dose-dependent manner
#17219
middle Confidence
Subject:
Doxorubicin
(Chemotherapy drugs)
→
induces
→
Object:
nucleophosmin_translocation
(Subcellular transport)
Original: DOX#induces#nucleophosmin translocation from the nucleolus to nucleoplasm and inhibits cell growth in a time- and dose-dependent manner
#17200
middle Confidence
Subject:
TASP1
(Protease)
→
interacts_with
→
Object:
NPM1
(Nucleolar proteins)
Original: Taspase1's nucleolar localization#required#autoproteolytic processing and interaction with nucleophosmin
#17199
middle Confidence
Subject:
TASP1
(Protease)
→
localizes_to
→
Object:
nucleolus
(Nucleolus)
Original: Taspase1's nucleolar localization#required#autoproteolytic processing and interaction with nucleophosmin
#17193
middle Confidence
Subject:
NPM1
(Ribosome-associated proteins)
→
has
→
Object:
growth-suppressive_role
(Cellular Processes)
Original: NPM#has#proliferative and growth-suppressive roles
#17192
middle Confidence
Subject:
NPM1
(Ribosome-associated proteins)
→
has
→
Object:
proliferative_role
(Cellular Processes)
Original: NPM#has#proliferative and growth-suppressive roles
#17180
middle Confidence
Subject:
NPM1
(Ribosome-associated proteins)
→
contributes_to
→
Object:
transfer_of_NPM1_from_iPNBs_to_nucleoli
(Molecular transport process)
Original: Diffusion of B23 molecules (NPM1)#contributes to#transfer of B23 from iPNBs to nucleoli
#17033
middle Confidence
Subject:
EAPB0503
(Small molecule drugs)
→
restores
→
Object:
wt-NPM1_nucleolar_localization
(Protein localization phenotype)
Original: EAPB0503#restores#wt-NPM1 nucleolar localization in NPM1c AML cells
#17032
middle Confidence
Subject:
EAPB0503
(Small molecule drugs)
→
induces
→
Object:
proteasome-mediated_degradation_of_NPM1c
(Protein degradation phenotype)
Original: EAPB0503#induces#proteasome-mediated degradation of NPM1c
#17015
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
blocks
→
Object:
increases_in_Arf(-/-)_osteoclast_activity
(Cellular Processes)
Original: Knockdown of NPM#blocks#increases in Arf(-/-) ribosome output and osteoclast activity
#17014
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
blocks
→
Object:
increases_in_Arf(-/-)_ribosome_output
(Molecular Process)
Original: Knockdown of NPM#blocks#increases in Arf(-/-) ribosome output and osteoclast activity
#17001
middle Confidence
Subject:
CDKN2A
(Cell cycle inhibitors)
→
regulates
→
Object:
cell_proliferation
(Cell proliferation)
Original: ARF#regulates#cell proliferation via inhibiting B23
#17000
middle Confidence
Subject:
CDKN2A
(Cell cycle inhibitors)
→
regulates
→
Object:
ribosome_biogenesis
(Ribosome biogenesis)
Original: ARF#regulates#ribosome biogenesis via inhibiting B23
#16999
middle Confidence
Subject:
NPM1
(Ribosomal proteins/nucleolar proteins)
→
overexpression_promotes
→
Object:
S_phase_entry
(Cell cycle progression)
Original: Overexpression of B23#promotes#S phase entry in cells lacking p53
#16998
middle Confidence
Subject:
NPM1
(Ribosomal proteins/nucleolar proteins)
→
overexpression_induces
→
Object:
cell_cycle_arrest
(Cell cycle arrest)
Original: Overexpression of B23#induces#cell cycle arrest in normal fibroblasts
#16962
middle Confidence
Subject:
ZNF692
(Transcription Factors)
→
mixed_with
→
Object:
NPM1
(Nucleolar proteins)
Original: NPM1 mixed with ZNF692#produces#irregular condensates resembling living cell nucleoli
#16961
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
mixed_with
→
Object:
ZNF692
(Transcription Factors)
Original: NPM1 mixed with ZNF692#produces#irregular condensates resembling living cell nucleoli
#16960
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
interacts_with
→
Object:
ZNF692
(Transcription Factors)
Original: ZNF692#interacts with#nucleophosmin 1 (NPM1)
#16959
middle Confidence
Subject:
ZNF692
(Transcription Factors)
→
interacts_with
→
Object:
NPM1
(Nucleolar proteins)
Original: ZNF692#interacts with#nucleophosmin 1 (NPM1)
#16956
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
interacts_with
→
Object:
ZNF692
(Transcription Factors)
Original: ZNF692#interacts with#NPM1
#16955
middle Confidence
Subject:
ZNF692
(Transcription Factors)
→
interacts_with
→
Object:
NPM1
(Nucleolar proteins)
Original: ZNF692#interacts with#NPM1
#16927
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
shuttles_between
→
Object:
Cytoplasm
(Organelles)
Original: Nucleophosmin (NPM)#shuttles between#nucleus and cytoplasm
#16926
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
shuttles_between
→
Object:
nucleus
(Organelles)
Original: Nucleophosmin (NPM)#shuttles between#nucleus and cytoplasm
#16909
middle Confidence
Subject:
ALK
(Receptor tyrosine kinases)
→
is_detected_in
→
Object:
neoplastic_cells
(Cell Type)
Original: Nucleophosmin (NPM)-ALK proteins#are detected in#normal and neoplastic cells
#16908
middle Confidence
Subject:
ALK
(Receptor tyrosine kinases)
→
is_detected_in
→
Object:
normal_cells
(Cell Type)
Original: Nucleophosmin (NPM)-ALK proteins#are detected in#normal and neoplastic cells
#16907
middle Confidence
Subject:
NPM-ALK
(Fusion Protein)
→
is_detected_in
→
Object:
neoplastic_cells
(Cell Type)
Original: Nucleophosmin (NPM)-ALK proteins#are detected in#normal and neoplastic cells
#16906
middle Confidence
Subject:
NPM-ALK
(Fusion Protein)
→
is_detected_in
→
Object:
normal_cells
(Cell Type)
Original: Nucleophosmin (NPM)-ALK proteins#are detected in#normal and neoplastic cells
#16902
middle Confidence
Subject:
Nucleophosmin
(Nucleolar proteins)
→
is_involved_in
→
Object:
cell_proliferation
(Cell proliferation)
Original: Nucleophosmin/protein B23#is involved in#ribosome maturation and cell proliferation
#16901
middle Confidence
Subject:
Nucleophosmin
(Nucleolar proteins)
→
is_involved_in
→
Object:
ribosome_maturation
(Ribosome maturation)
Original: Nucleophosmin/protein B23#is involved in#ribosome maturation and cell proliferation
#16896
middle Confidence
Subject:
Nucleophosmin_1
(Ribosomal proteins)
→
is_involved_in
→
Object:
genome_stability
(Genome stability)
Original: Nucleophosmin 1#is involved in#ribosome biogenesis/ stress responses/ and genome stability
#16895
middle Confidence
Subject:
Nucleophosmin_1
(Ribosomal proteins)
→
is_involved_in
→
Object:
stress_responses
(Cellular stress response)
Original: Nucleophosmin 1#is involved in#ribosome biogenesis/ stress responses/ and genome stability
#16894
middle Confidence
Subject:
Nucleophosmin_1
(Ribosomal proteins)
→
is_involved_in
→
Object:
ribosome_biogenesis
(Ribosome biogenesis)
Original: Nucleophosmin 1#is involved in#ribosome biogenesis/ stress responses/ and genome stability
#16883
middle Confidence
Subject:
KLF16
(Transcription Factors)
→
interacts_with
→
Object:
FBL
(Nucleolar proteins)
Original: KLF16#interacts with#NPM1 and FBL for nucleolar homeostasis
#16882
middle Confidence
Subject:
KLF16
(Transcription Factors)
→
interacts_with
→
Object:
NPM1
(Nucleolar proteins)
Original: KLF16#interacts with#NPM1 and FBL for nucleolar homeostasis
#16819
middle Confidence
Subject:
NPM1
(Protein coding genes)
→
loss
→
Object:
Stabilization_of_c-Myc
(Protein stability)
Original: NPM1 loss#stabilizes#c-Myc
#16791
middle Confidence
Subject:
loss_of_NPM_nucleolar_localization
(Abnormal subcellular localization)
→
leads_to
→
Object:
loss_of_functions_in_DNA-damage_repair
(Molecular Process)
Original: Loss of NPM nucleolar localization#leads to#a loss of functions in ribosome biogenesis or DNA-damage repair
#16790
middle Confidence
Subject:
loss_of_NPM_nucleolar_localization
(Abnormal subcellular localization)
→
leads_to
→
Object:
loss_of_functions_in_ribosome_biogenesis
(Molecular Process)
Original: Loss of NPM nucleolar localization#leads to#a loss of functions in ribosome biogenesis or DNA-damage repair
#16771
middle Confidence
Subject:
nucleophosmin
(Ribosome-associated proteins)
→
associated_with
→
Object:
ribosome_maturation
(Ribosome maturation process)
Original: nucleophosmin/protein B23#is associated with#ribosome maturation and cellular proliferation
#16550
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
could_serve_as
→
Object:
differential_diagnostic_criteria_for_leiomyosarcoma
(Diagnostic criteria)
Original: The index of area and integral optical density of NPM#could serve as#differential diagnostic criteria for cellular and mitotically active leiomyomas and well-differentiated leiomyosarcoma
#16549
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
could_serve_as
→
Object:
differential_diagnostic_criteria_for_leiomyomas
(Diagnostic criteria)
Original: The index of area and integral optical density of NPM#could serve as#differential diagnostic criteria for cellular and mitotically active leiomyomas and well-differentiated leiomyosarcoma
#16548
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
is_expressed_in
→
Object:
smooth_muscle_tumors_of_corpus_uteri
(Tumor tissue)
Original: B23/Nucleophosmin#is expressed in#smooth muscle tumors of the corpus uteri
#15669
middle Confidence
Subject:
p120
(Nucleoprotein)
→
was_studied_in
→
Object:
prostatic_carcinoma_tissue
(Cancer tissue)
Original: Expression of p120 and B23#was studied in#prostatic carcinoma cell line (LNCaP) and tissue sections
#15668
middle Confidence
Subject:
p120
(Nucleoprotein)
→
was_studied_in
→
Object:
prostatic_carcinoma_cell_line
(Cancer cell lines)
Original: Expression of p120 and B23#was studied in#prostatic carcinoma cell line (LNCaP) and tissue sections
#12663
middle Confidence
Subject:
NPM1
(Ribosomal proteins)
→
inhibits
→
Object:
cell_growth
(Cellular Processes)
Original: Short exposure to DOX#induces#dose-response nucleophosmin translocation and cell growth inhibition
#12662
middle Confidence
Subject:
NPM1
(Ribosomal proteins)
→
translocates
→
Object:
nucleoplasm
(Subcellular structure)
Original: Short exposure to DOX#induces#dose-response nucleophosmin translocation and cell growth inhibition
#12661
middle Confidence
Subject:
Nucleophosmin
(Nucleolar proteins)
→
is_localized_in
→
Object:
HL-60_cells
(Cell lines)
Original: Nucleophosmin (protein B23)#is localized in#HL-60 cells after incubation with DOX in the absence and presence of DPM
#12636
middle Confidence
Subject:
inhibition_of_rRNA_synthesis
(Molecular Process)
→
induces
→
Object:
p53_activation
(Protein activation)
Original: Inhibition of rRNA synthesis#induces#nucleoplasmic translocation of NPM1 and p53 activation
#12635
middle Confidence
Subject:
inhibition_of_rRNA_synthesis
(Molecular Process)
→
induces
→
Object:
nucleoplasmic_translocation_of_NPM1
(Cellular Processes)
Original: Inhibition of rRNA synthesis#induces#nucleoplasmic translocation of NPM1 and p53 activation
#12601
middle Confidence
Subject:
NPM1_depletion
(Reduced protein expression)
→
accelerates
→
Object:
iPNBs_disassembly
(Subcellular structural changes)
Original: B23 depletion#accelerates#disassembly
#12600
middle Confidence
Subject:
NPM1
(Ribosome-associated proteins)
→
retards
→
Object:
iPNBs_disassembly
(Subcellular structural changes)
Original: Increased nucleoplasmic B23 content#retards#disassembly
#12599
middle Confidence
Subject:
pre-rRNA
(rRNA molecules)
→
interacts_with
→
Object:
NPM1
(Ribosome-associated proteins)
Original: Pre-rRNA molecules#interact with#B23 and lead to its accumulation within nucleoli
#12565
middle Confidence
Subject:
NPM1
(Ribosome-associated proteins)
→
is_involved_in
→
Object:
ribosomal_RNA_synthesis_and_processing
(Ribosome biogenesis)
Original: NPM1#is involved in#synthesis and processing of ribosomal RNA
#12525
middle Confidence
Subject:
NPM1
(Nucleolar phosphoprotein)
→
is_related_with
→
Object:
molecular_mechanisms_of_NPM1c
(Molecular mechanism)
Original: Findings#could pave the way into#molecular mechanisms of NPM1c
#12479
middle Confidence
Subject:
SENP3
(Deubiquitinase)
→
binds_to
→
Object:
NPM1
(Nucleolar proteins)
Original: Stabilization and localization of p19(Arf) and Senp3#depend upon#binding to nucleophosmin
#12478
middle Confidence
Subject:
CDKN2A
(Tumor suppressor proteins)
→
binds_to
→
Object:
NPM1
(Nucleolar proteins)
Original: Stabilization and localization of p19(Arf) and Senp3#depend upon#binding to nucleophosmin
#12431
middle Confidence
Subject:
NPM1
(Ribosomal proteins/nucleolar proteins)
→
knockdown_induces
→
Object:
cell_death
(Cell Death)
Original: Knocking down B23#induces#cell death
#12430
middle Confidence
Subject:
NPM1
(Ribosomal proteins/nucleolar proteins)
→
knockdown_inhibits
→
Object:
preribosomal_RNA_processing
(rRNA processing)
Original: Knocking down B23#inhibits#processing of preribosomal RNA
#12425
middle Confidence
Subject:
MYC
(Transcription Factors)
→
is_involved_in
→
Object:
oncogenesis
(Tumorigenesis)
Original: GLTSCR2#is involved in#oncogenesis with p53/ NPM/ and MYC
#12424
middle Confidence
Subject:
NPM1
(Nucleolar phosphatase)
→
is_involved_in
→
Object:
oncogenesis
(Tumorigenesis)
Original: GLTSCR2#is involved in#oncogenesis with p53/ NPM/ and MYC
#12423
middle Confidence
Subject:
GLTSCR2
(Tumor suppressor-related proteins)
→
is_involved_in
→
Object:
oncogenesis
(Tumorigenesis)
Original: GLTSCR2#is involved in#oncogenesis with p53/ NPM/ and MYC
#12422
middle Confidence
Subject:
MYC
(Transcription Factors)
→
is_involved_in
→
Object:
tumor_suppression
(Tumor suppressor function)
Original: GLTSCR2#is involved in#tumor suppression with p53/ NPM/ and MYC
#12421
middle Confidence
Subject:
NPM1
(Nucleolar phosphatase)
→
is_involved_in
→
Object:
tumor_suppression
(Tumor suppressor function)
Original: GLTSCR2#is involved in#tumor suppression with p53/ NPM/ and MYC
#12420
middle Confidence
Subject:
GLTSCR2
(Tumor suppressor-related proteins)
→
is_involved_in
→
Object:
tumor_suppression
(Tumor suppressor function)
Original: GLTSCR2#is involved in#tumor suppression with p53/ NPM/ and MYC
#12416
middle Confidence
Subject:
NPM1
(Nucleolar phosphatase)
→
depletion_promotes
→
Object:
rDNA_transcription
(Transcription process)
Original: Knockdown of DNMT3A#enhanced#rDNA transcription in NPM1-depleted U1242MG cells
#12415
middle Confidence
Subject:
DNMT3A
(DNA methyltransferase)
→
knockdown_enhances
→
Object:
rDNA_transcription
(Transcription process)
Original: Knockdown of DNMT3A#enhanced#rDNA transcription in NPM1-depleted U1242MG cells
#12340
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
plays_role_in
→
Object:
nucleolus
(Cellular substructure)
Original: Tumor suppressors and proto-oncogenes#play#a direct role in the nucleolus and interact with RNA polymerase I machinery
#12339
middle Confidence
Subject:
MYC
(Oncogene)
→
plays_role_in
→
Object:
nucleolus
(Cellular substructure)
Original: Tumor suppressors and proto-oncogenes#play#a direct role in the nucleolus and interact with RNA polymerase I machinery
#12338
middle Confidence
Subject:
BRCA1
(Tumor suppressor genes)
→
plays_role_in
→
Object:
nucleolus
(Cellular substructure)
Original: Tumor suppressors and proto-oncogenes#play#a direct role in the nucleolus and interact with RNA polymerase I machinery
#12337
middle Confidence
Subject:
PICT1
(Nucleolus-associated protein)
→
plays_role_in
→
Object:
nucleolus
(Cellular substructure)
Original: Tumor suppressors and proto-oncogenes#play#a direct role in the nucleolus and interact with RNA polymerase I machinery
#12336
middle Confidence
Subject:
PTEN
(Tumor suppressor genes)
→
plays_role_in
→
Object:
nucleolus
(Cellular substructure)
Original: Tumor suppressors and proto-oncogenes#play#a direct role in the nucleolus and interact with RNA polymerase I machinery
#12335
middle Confidence
Subject:
RB1
(Tumor suppressor genes)
→
plays_role_in
→
Object:
nucleolus
(Cellular substructure)
Original: Tumor suppressors and proto-oncogenes#play#a direct role in the nucleolus and interact with RNA polymerase I machinery
#12334
middle Confidence
Subject:
TP53
(Tumor suppressor genes)
→
plays_role_in
→
Object:
nucleolus
(Cellular substructure)
Original: Tumor suppressors and proto-oncogenes#play#a direct role in the nucleolus and interact with RNA polymerase I machinery
#12329
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
predominantly_resides_in
→
Object:
nucleolus
(Organelles)
Original: NPM1#predominantly resides in#nucleolus
#12326
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
contains
→
Object:
nucleolar_localization_signal
(Protein signal peptide)
Original: NPM1#contains#nucleolar localization signal in its C-terminal region
#12325
middle Confidence
Subject:
ATF5
(Transcription Factors)
→
binds_to
→
Object:
NPM1_C-terminal_region
(Protein domain)
Original: ATF5#binds to#C-terminal region of NPM1
#12274
middle Confidence
Subject:
NPM1
(Ribosome-associated proteins)
→
regulates
→
Object:
TP53_transcriptional_activation
(Transcriptional activation process)
Original: NPM#interacts with#tumor suppressor p53 to regulate stability and transcriptional activation
#12273
middle Confidence
Subject:
NPM1
(Ribosome-associated proteins)
→
regulates
→
Object:
TP53_stability
(Protein stability)
Original: NPM#interacts with#tumor suppressor p53 to regulate stability and transcriptional activation
#12272
middle Confidence
Subject:
NPM1
(Ribosome-associated proteins)
→
interacts_with
→
Object:
TP53
(Tumor suppressor proteins)
Original: NPM#interacts with#tumor suppressor p53 to regulate stability and transcriptional activation
#12189
middle Confidence
Subject:
small_molecules
(Small molecules)
→
target
→
Object:
mutated_npm1_interactions
(Protein Interactions)
Original: Small molecules#can target#mutated NPM1 interactions
#12188
middle Confidence
Subject:
NPM1
(Protein coding genes)
→
mutation
→
Object:
tryptophan_disruption
(Abnormal protein structure)
Original: NPM1 mutations#create#a nuclear export signal and disrupt tryptophans
#12187
middle Confidence
Subject:
NPM1
(Protein coding genes)
→
mutation
→
Object:
nuclear_export_signal_creation
(Signal Generation)
Original: NPM1 mutations#create#a nuclear export signal and disrupt tryptophans
#12181
middle Confidence
Subject:
NPM1
(Protein coding genes)
→
is_required_for
→
Object:
stabilization_of_FBW7gamma
(Protein stability)
Original: NPM#is required for#nucleolar localization and stabilization of Fbw7gamma
#12180
middle Confidence
Subject:
NPM1
(Protein coding genes)
→
is_required_for
→
Object:
nucleolar_localization_of_FBW7gamma
(Subcellular localization)
Original: NPM#is required for#nucleolar localization and stabilization of Fbw7gamma
#12159
middle Confidence
Subject:
PES1
(Nucleolar proteins)
→
is_a_member_of
→
Object:
key_nucleolar_protein
(protein)
Original: key nucleolar proteins#included#Nucleolin/ Nucleophosmin-1/ Glypican-2/ and PES-1
#12158
middle Confidence
Subject:
GPC2
(Glycoprotein)
→
is_a_member_of
→
Object:
key_nucleolar_protein
(protein)
Original: key nucleolar proteins#included#Nucleolin/ Nucleophosmin-1/ Glypican-2/ and PES-1
#12157
middle Confidence
Subject:
NPM1
(Ribosomal proteins)
→
is_a_member_of
→
Object:
key_nucleolar_protein
(protein)
Original: key nucleolar proteins#included#Nucleolin/ Nucleophosmin-1/ Glypican-2/ and PES-1
#12156
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
is_a_member_of
→
Object:
key_nucleolar_protein
(protein)
Original: key nucleolar proteins#included#Nucleolin/ Nucleophosmin-1/ Glypican-2/ and PES-1
#12137
middle Confidence
Subject:
nucleophosmin
(Ribosome-associated proteins)
→
associated_with
→
Object:
cellular_proliferation
(Cell proliferation process)
Original: nucleophosmin/protein B23#is associated with#ribosome maturation and cellular proliferation
#12133
middle Confidence
Subject:
nucleophosmin
(Ribosomal proteins)
→
is_associated_with
→
Object:
interphase_AgNORs
(Nucleolus-related organic silver reactants)
Original: Nucleolin and nucleophosmin#are associated with#interphase AgNORs
#12132
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
is_associated_with
→
Object:
interphase_AgNORs
(Nucleolus-related organic silver reactants)
Original: Nucleolin and nucleophosmin#are associated with#interphase AgNORs
#12048
middle Confidence
Subject:
cucurbitacin_B
(Small molecule compounds)
→
induces
→
Object:
translocation_of_nucleophosmin/B23_from_nucleolus_to_nucleoplasm
(Changes in protein localization)
Original: cucurbitacin B#induces#translocation of nucleophosmin/B23 from nucleolus to nucleoplasm
#12027
middle Confidence
Subject:
NPM1
(Ribosome-associated proteins)
→
is_required_for
→
Object:
proliferation
(Cellular Processes)
Original: nucleophosmin (NPM/B23)#is required for#proliferation
#11665
middle Confidence
Subject:
NPM1
(Ribosomal proteins)
→
depletion_altered
→
Object:
silver_staining_of_nucleolar_organizer_regions
(Molecular test results)
Original: NPM1 depletion#altered#silver staining of nucleolar organizer regions in U1242MG glioma cells
#10772
middle Confidence
Subject:
NPM1
(Ribosome-associated proteins)
→
transfers_between
→
Object:
iPNBs_and_nucleoli
(Subcellular structure)
Original: B23#transfers between#iPNBs and nucleoli through a nucleoplasmic pool
#10754
middle Confidence
Subject:
CDKN2A
(Tumor suppressor proteins)
→
antagonizes
→
Object:
SENP3_function
(Protein function)
Original: Senp3 and p19(Arf)#antagonize#each other's functions in SUMOylation regulation
#10753
middle Confidence
Subject:
SENP3
(Deubiquitinase)
→
antagonizes
→
Object:
CDKN2A_function
(Protein function)
Original: Senp3 and p19(Arf)#antagonize#each other's functions in SUMOylation regulation
#10709
middle Confidence
Subject:
NPM1
(Ribosome-associated proteins)
→
regulates
→
Object:
nucleolar_localization_of_DNA_repair_enzymes
(Subcellular localization process)
Original: NPM1#modulates#the BER pathway and nucleolar localization of enzymes
#10708
middle Confidence
Subject:
NPM1
(Ribosome-associated proteins)
→
modulates
→
Object:
BER_pathway
(DNA repair pathways)
Original: NPM1#modulates#the BER pathway and nucleolar localization of enzymes
#10679
middle Confidence
Subject:
MDM2
(E3 ubiquitin ligase)
→
outcompetes
→
Object:
NPM1
(Ribosome-associated proteins)
Original: Mdm2 oncogene#outcompetes#NPM/B23 for ARF binding
#6655
middle Confidence
Subject:
efficient_cytoplasmic_export
(Molecular Process)
→
is_critical_for
→
Object:
Leukaemogenesis
(Disease occurrence)
Original: NPM1 mutants#are selected for#efficient cytoplasmic export critical for leukaemogenesis
#6654
middle Confidence
Subject:
NPM1_mutant
(protein)
→
is_selected_for
→
Object:
efficient_cytoplasmic_export
(Molecular Process)
Original: NPM1 mutants#are selected for#efficient cytoplasmic export critical for leukaemogenesis
#6653
middle Confidence
Subject:
Nucleophosmin_export
(Molecular Process)
→
is_maximum_with
→
Object:
all_three_NES_motifs
(Protein domain)
Original: Nucleophosmin export#is maximum with#all three NES motifs in NPM1-mutated AML
#6627
middle Confidence
Subject:
p14
(Tumor suppressor proteins)
→
coimmunoprecipitates_with
→
Object:
B23
(Nucleolar proteins)
Original: p14#coimmunoprecipitates with#B23
#6539
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
regulates
→
Object:
SENP3_turnover
(Protein stability)
Original: p19(Arf)#depends on#Npm for Senp3 turnover
#6538
middle Confidence
Subject:
CDKN2A
(Tumor suppressor proteins)
→
depends_on
→
Object:
NPM1
(Nucleolar proteins)
Original: p19(Arf)#depends on#Npm for Senp3 turnover
#6411
middle Confidence
Subject:
Cisplatin
(Chemotherapy drugs)
→
induces
→
Object:
relocalization_of_BER_components
(DNA repair protein localization)
Original: Cisplatin treatment#leads to#relocalization of NPM1 and BER components from nucleoli to nucleoplasm
#6410
middle Confidence
Subject:
Cisplatin
(Chemotherapy drugs)
→
induces
→
Object:
relocalization_of_NPM1
(Protein subcellular localization)
Original: Cisplatin treatment#leads to#relocalization of NPM1 and BER components from nucleoli to nucleoplasm
#6405
middle Confidence
Subject:
blocky_R-MCD_peptide
(Synthetic peptides)
→
undergoes_LLPS_with
→
Object:
NPM1
(Nucleolar proteins)
Original: Blocky R-MCD peptide#underwent#LLPS with affinity to RNA/ acidic poly-Glu/ and acidic nucleolar protein nucleophosmin
#6404
middle Confidence
Subject:
blocky_R-MCD_peptide
(Synthetic peptides)
→
undergoes_LLPS_with
→
Object:
acidic_poly-Glu
(Peptides)
Original: Blocky R-MCD peptide#underwent#LLPS with affinity to RNA/ acidic poly-Glu/ and acidic nucleolar protein nucleophosmin
#6403
middle Confidence
Subject:
blocky_R-MCD_peptide
(Synthetic peptides)
→
undergoes_LLPS_with
→
Object:
RNA
(Nucleic Acids)
Original: Blocky R-MCD peptide#underwent#LLPS with affinity to RNA/ acidic poly-Glu/ and acidic nucleolar protein nucleophosmin
#6400
middle Confidence
Subject:
PPAN
(Ribosome biogenesis-associated protein)
→
depletion_induces
→
Object:
UBTF_degradation
(Protein degradation)
Original: PPAN depletion#induces#NPM and upstream-binding factor (UBF) degradation
#6399
middle Confidence
Subject:
PPAN
(Ribosome biogenesis-associated protein)
→
depletion_induces
→
Object:
NPM1_degradation
(Protein degradation)
Original: PPAN depletion#induces#NPM and upstream-binding factor (UBF) degradation
#6398
middle Confidence
Subject:
PPAN
(Ribosome biogenesis-associated protein)
→
interacts_with
→
Object:
NPM1
(Nucleolar proteins)
Original: PPAN#is a novel interaction partner of#the anti-apoptotic protein nucleophosmin (NPM)
#6306
middle Confidence
Subject:
NPM1
(Ribosome-associated proteins)
→
binds_to
→
Object:
CDKN2A
(Tumor suppressor proteins)
Original: Mdm2 oncogene#outcompetes#NPM/B23 for ARF binding
#5968
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
is_associated_with
→
Object:
nucleolus-producing_regions
(Cellular substructure)
Original: B23/Nucleophosmin#is associated with#nucleolus-producing regions
#5060
middle Confidence
Subject:
NPM1
(Ribosome-associated proteins)
→
is_involved_in
→
Object:
nucleocytoplasmic_shuttling
(Cellular Processes)
Original: ARF induction#prevents#nucleocytoplasmic shuttling of NPM/B23
#5059
middle Confidence
Subject:
CDKN2A
(Tumor suppressor proteins)
→
induces
→
Object:
NPM1
(Ribosome-associated proteins)
Original: ARF induction#prevents#nucleocytoplasmic shuttling of NPM/B23
#4525
middle Confidence
Subject:
NES_motifs
(Protein domain)
→
mediate
→
Object:
NPM1_heterodimerization
(Protein complex)
Original: NES motifs#mediate#NPM1 homo/heterodimerization
#4524
middle Confidence
Subject:
NES_motifs
(Protein domain)
→
mediate
→
Object:
NPM1_homodimerization
(Protein complex)
Original: NES motifs#mediate#NPM1 homo/heterodimerization
#2978
low Confidence
Subject:
MS
(Tumor type)
→
may_occur_less_frequently_in
→
Object:
APL_with_PML_RARA
(Disease subtype)
Original: MS#may occur more frequently in#APL with NPM1/RARA than APL with PML/RARA
#2977
low Confidence
Subject:
MS
(Tumor type)
→
may_occur_more_frequently_in
→
Object:
APL_with_NPM1_RARA
(Disease subtype)
Original: MS#may occur more frequently in#APL with NPM1/RARA than APL with PML/RARA